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从循证证据角度——看吉西他滨在淋巴瘤治疗中的应用价值

2020-07-30/ 安溪股票配资 网/ 查看: 214/ 评论: 10

摘要淋巴瘤是原发于淋巴结和(或)结外淋巴组织的血液系统恶性肿瘤。根据病理类型可分为霍奇金淋巴瘤(HL)及非

LINBALIUSHIYUANFAYULINBAJIEHE(HUO)JIEWAILINBAZUZHIDEXUEYEXITONGEXINGZHONGLIU。GENJUBINGLILEIXINGKEFENWEIHUOQIJINLINBALIU(HL)JIFEIHUOQIJINLINBALIU(NHL),NHLGENJUXIBAOLAIYUANFENWEIBXIBAOXINGLINBALIUHET/NKXIBAOXINGLINBALIU;YIJUQISHENGWUXUEXINGWEIYOUFENWEIQINXIXINGLINBALIUJIDUOXINGLINBALIU。BUTONGLEIXINGDELINBALIUQIZUZHILEIXING、SHENGWUXUEXINGWEI、ZIRANBINGCHENGJIZHILIAOXIAOGUOCUNZAIJUDACHAYI。LINBALIUYIJINGCHENGWEIZHONGLIUXUEHEXUEYEBINGXUEZUINANZHANGWODEJIBING,SUIZHEHUALIAOFANGANDEBUDUANGAIJINJIZAOXUEGANXIBAOYIZHIJISHUDEWANSHAN,BAXIANGZHILIAOYAOWUDEBUDUANCHENGGONGYINRU,LINBALIUHUANZHEDEZHANGQISHENGCUNBILIDEDAOLEXIANZHUTIGAO,DANRENGYOUYIDINGBILIHUANZHEMIANLINJIBINGNANZHIHUOFUFA,CILEIHUANZHEYUHOUCHA,ERZHILIAOMUQIANSHANGWUTONGYIBIAOZHUN。

龙岩炒股配资 JIXITABIN(JIANZE)SHIYIZHONGMIDINGLEISIWU,TONGGUOGANRAOXIBAODNAHECHENGYUXIUFU、GANRAORNAHECHENGDENGDADAOYIZHIZHONGLIUXIBAOSHENGZHANG、YOUDAODIAOWANGDEZUOYONG。YUATANGBAOGANXIANGBI,JIXITABINDEKANGZHONGLIUHUOXINGQIANG、ZUOYONGCHIJIUQIEDUOXIANGYANJIUBIAOMINGQIBULIANGFANYINGSHAO。JINNIANLAI,DUOXIANGBAOHANJIXITABINHUALIAOFANGANDEZHANGQISUIFANGJIEGUOLINGRENGUWU。XIANZHENGLIXIANGGUANJINZHAN,SHULIYIJIXITABINWEIDAIBIAODEHUALIAOZHILIAOZAILINBALIUZHILIAOZHONGSUOFAHUIDEZUOYONG。

难治或复发霍奇金淋巴瘤领域的化疗治疗进展


HLSHIQINGNIANRENZHONGZUICHANGJIANDEEXINGZHONGLIUZHIYI,DANWOGUOHLFABINGLVJIAODI,ZHIZHANEXINGLINBALIUDE10%~15%。

QIBINGLILEIXINGKEFENWEIJINGDIANHUOQIJINLINBALIU(CHL)YUJIEJIEXINGLINBAXIBAOWEIZHUXINGHUOQIJINLINBALIU(NLPHL)。SUIZHEABVD(AMEISU+BOLAIMEISU+ZHANGCHUNHUAJIAN+DANXIZUOAN)FANGANDEPUJIYINGYONG,SHI80%HLHUANZHEHUODEZHANGQISHENGCUN,DANRENGYOU30%~40%DEHUANZHECHUXIANJIBINGJINZHAN,LINGWAI10%~15%DEHUANZHECUNZAIYUANFANAIYAO。

龙岩炒股配资 MUQIANTUIJIANNANZHIHUOFUFADEHUANZHESHOUXUANDAJILIANGHUALIAOHOUZITIZAOXUEGANXIBAOYIZHI(HDT/ASCT),DANYIZHIQIANHUANZHESHIFOUWANQUANHUANJIE(CR)ZHUANGTAIZHIJIEYINGXIANGHUANZHEWUJINZHANSHENGCUN(PFS)LVJIZONGSHENGCUN(OS)LV,YINCIYIZHIQIANWANJIUHUALIAOFANGANDEXUANZEZHIGUANZHONGYAO。

YIDALIYIXIANGYANJIUNARU91LINANZHIHUOFUFAHLHUANZHE,JIYUIGEV(YIHUANLINXIANAN+JIXITABIN+ZHANGCHUNRUIBIN)FANGAN,4ZHOUQIHOU49LIHUANZHE(53.8%)HUODECR,25LI(27.5%)DADAOBUFENHUANJIE(PR),KEGUANHUANJIELV(ORR)WEI81.3%,ZITIGANXIBAODONGYUANCAIJICHENGGONGLVDA98.7%。BULIANGFANYINGRONGYINAISHOU,WEIFASHENG4DUGUSUIYIZHI,WUZHILIAOXIANGGUANSIWANGSHIJIAN。ERQIE,GAIFANGANGANXIBAODUXINGBIJIAOXIAO,DUIHOUXUGANXIBAOCHENGGONGDONGYUANDAYOUBIYI。

TONGNIANCALGB 59804 YANJIUCAIYONGGVD(JIXITABIN+ZHANGCHUNRUIBIN+ZHIZHITIDUOROUBIXING)FANGANZHILIAO91LINANZHIHUOFUFAHLHUANZHE,ORRWEI70%,19%DACR。WUASCT ZUGVD FANGANHOUXINGASCT,4NIANPFSLVJIOSLVFENBIEWEI52%HE70%,YOUASCTSHIHUANZHEFENBIEWEI10%HE34%。

龙岩炒股配资 ZHONGSHANDAXUEZHONGLIUYIYUANTUANDUIYIZAI2014NIANFABIAOLEGVDZHILIAOZHONGGUOFUFANANZHIHLDESHOUPIANWENZHANG,LIAOXIAOYUMEIGUOBAODAOXIANGSI,GENGZHONGYAODESHIGVDRANGBUFENWUFAJINXINGASCTDEHUANZHEZHONGXINHUODEJIHUI,BINGQIEGVDHUANJIEHOUASCTGONGGUZHILIAODEYUANQIXIAOGUOXIANGDUIMANYI。

LINGWAI,YIYOUYANJIUXIANSHIGDPFANGAN(JIXITABIN+DISAIMISONG+SHUNBO)ZHILIAONANZHIHUOFUFAHLDEYOUXIAOLVKEDA62%~70%。

龙岩炒股配资 2014NIANOUZHOUNEIKEZHONGLIUXUEHUI(ESMO)ZHINANTUIJIANNANZHIHUOFUFAHLHUANZHE,KECAIYONGIGEVFANGANJIANDIZHONGLIUFUHEJIXINGGANXIBAODONGYUANHOUXINGHDT/ASCT。2016NIANMEIGUOGUOJIAAIZHENGZONGHEWANGLUO(NCCN)ZHINANTUIJIANHANJIXITABINDEZHILIAOFANGANRUGVD,IGEVDENGWEIZHUYAODEZHILIAONANZHIHUOFUFAHLWANJIUFANGAN。

非霍奇金淋巴瘤中以吉西他滨为基础的方案发挥重要作用


NHLBINGLILEIXINGFUZA,BUTONGDELINCHUANGFENQI、FENZISHENGWUXUESHUIPINGDENGZHUDUOYINSUJUNHUIYINGXIANGZHILIAODEXUANZE。

ZAIWOGUO,T XIBAOLINBALIU、GAODUEXINGLINBALIUJIJIEWAINHL DEFABINGLVJUNGAOYUOUMEIGUOJIA。JINGYIXIANZHILIAODEHUANZHEZHONG,ZHISHAO20%ZUOYOUDEQINXIXINGNHLZHILIAOWUXIAO,ZHILIAOYOUXIAODEHUANZHE30%HUIZAIHUANJIEHOUHUIFUFA,TEBIESHITXIBAOLINBALIU。

龙岩炒股配资 SUIRANMUQIANZHENDUICD20、CD30 DENGBADIANDEFENZIBAXIANGYAOWUYINGYONGYULINCHUANGHOUSHIDELINBALIUDEZHIYULVXIANZHUTIGAO,DANWANJIUXINGHUALIAOYIRANSHIMUQIANZHILIAONANZHIHUOFUFALINBALIUDEZHUYAOZHILIAOSHOUDUAN。

B细胞淋巴瘤

龙岩炒股配资 MIMANDABXIBAOLINBALIU(DLBCL)SHICHENGRENCHANGJIANDEQINXIXINGNHL,R-CHOP(LITUOXIDANKANG+HUANLINXIANAN+AMEISU+ ZHANGCHUNXINJIAN+ PONISONG)FANGANSHIMUQIANTUIJIANDEYIXIANZHILIAOFANGAN,QIMINGXIANTIGAOLEYOUXIAOLV,YANZHANGHUANZHEDEWUJIBINGJINZHAN(DFS)QI,DANRENGYOU50%~60%DEHUANZHECHUXIANYUANFANAIYAOHUOFUFACONGERSHIJIBINGJINZHANDAOZHIHUANZHESIWANG。

龙岩炒股配资 YIXIANGQIANZHANXINGYANJIUNARULE96 LI60~70 SUINANZHIHUOFUFADLBCLHUANZHE,SUIJIFENWEI2 ZU。A ZU48 LIHUANZHE, QIZHONGFUFAWEI27 LI(56.3%),NANZHIWEI21 LI(43.7%),JIESHOUESHAP(YITUOBOGAN+SHUNBO+JIAJIQIANGDESONGLONG+ATANGBAOGAN)FANGANZHILIAO;B ZU48 LI,QIZHONGFUFAWEI28LI(58%),NANZHIWEI20LI(42%),JIESHOUGDPFANGANZHILIAO。JIEGUOXIANSHI,GDPZUHUANZHEORR(63%)JI3 NIANOS LV(20.5%)XIANZHUGAOYUESHAP ZU(55% HE11.8%),P=0.01。GDPZUDE3NIANPFSLVYUWUSHIJIANSHENGCUN(EFS)LVFENBIEWEI20.5%HE19.7%,YOUYUESHAPZU(10.9%HE11.1%)。CIWAI,MEIGUOQIANZHANXINGSUIJIDUIZHAONCIC CTG STUDY LY12YANJIUJIEGUOBIAOMING,GDPLIAOXIAOYUDHAPXIANGSI,DANGDPBULIANGFANYINGMINGXIANGENGDI,ZHEISHIMUQIANYOUGUANXIBAODUYAOWUZHILIAOFUFANANZHIBXIBAOLINBALIUDEZUIGAOZHILIANGLINCHUANGYANJIU,YINCI,GENJUBENLINCHUANGYANJIUDEJIEGUO,ZUOZHERENWEIGDPSHIASCTQIANYOUXUANDEWANJIUHUALIAOFANGAN。

FAGUOYIXIANGYANJIUZHONG,CAIYONGR-GemOx(PEIMENDONGMEI+JIXITABIN+AOSHALIBO)FANGANDECRLVKEDA44%,PRLVDA17%,5NIANPFSLVJIOSLVFENBIEWEI12.8% HE13.9%。

LINGYIXIANGYANJIUCAIYONGGDPFANGANZHILIAO152LINANZHIHUOFUFADLBCLHUANZHE,ORRWEI49%,16%DADAOCR,2NIANPFS JIOS FENBIEWEI21%HE28%,ZHILIAO2~3 ZHOUQIHOUDADAOPRYISHANGHUANZHEXINGMIANYIXIUFULIAOFA(SCT),2 NIANPFS、OSFENBIEWEI36%HE46%。

龙岩炒股配资 JIYUDUOXIANGLINCHUANGYANJIUSHUJU,2012NIANKAISHINCCNZHINANYIJIANGGDP、GemOxFANGANLIERUNANZHIHUOFUFAHUANZHEDEWANJIUZHILIAOFANGANDANGZHONG,GemoxFANGANBIJIAOWENHE,TEBIESHIHENIANLINGHESHENTIZHUANGTAIBUJIADEHUANZHE。

DLBCL HUANZHELIANGHAODELIAOXIAOCUSHIRENMENTANTAOSHIYONGJIXITABINZHILIAOQITABXIBAOLINBALIU。YIXIANGYANJIUYINGYONGR-GDP FANGANZHILIAONANZHIHUOFUFABXIBAOLINBALIU,QIZHONGDLBCLHUANZHE30LI,3bJILVPAOLINBALIU(FL)20LI,2ZHOUQIHUALIAOJIESHUHOU,ORRWEI72%,CRLVWEI56%,HOUXU21LIXINGASCT,2NIANOSLVJIPFSLVFENBIEWEI70.0%HE48.0%。

龙岩炒股配资 TAOXIBAOLINBALIU(MCL)SHIYILEIQINXIXINGNHL,GUIFANZHILIAOXIARENGJIYIFUFA。YIXIANGYANJIUXIANSHI,DANYONGJIXITABINZHILIAO18 LIMCL LAONIANHUANZHE,ORR WEI28%,ZHONGWEIPFS QIWEI8 GEYUE,ZHILIAOFANYINGCHIXUSHIJIAN(TRD)WEI10.6GEYUE,QIEWEICHUXIANMINGXIANXUEYEXUEDUXING。

T/NK 细胞淋巴瘤

WAIZHOUT XIBAOLINBALIU(PTCL)SHIYIZUYIZHIXINGHENQIANGDELAIYUANYUCHENGSHUTXIBAOHUOXIONGXIANHOUT XIBAOJIBINGDEZONGHE,BAOKUOHENDUOZHONGYAXING,QIZHONGYIPTCL FEITEZHIXING(PTCL-U)ZUIWEICHANGJIAN,YUHOUCHA,QIJINSHANGWUBIAOZHUNZHILIAOFANGAN。YICHOP(HUANLINXIANAN+AMEISU+ZHANGCHUNXINJIAN+PONISONG)WEIDAIBIAODEHUALIAOFANGANDUIYUPTCL DELIAOXIAOQIANJIA,5NIANSHENGCUNLVJINWEI20%~42%。JIWANGDUOXIANGLINCHUANGYANJIUTISHI,JIXITABINSHIZHILIAOPTCLBIJIAOYOUXIAODEXIBAODUYAOWU。

JINNIANDELINCHUANGYANJIUXIANSHI,JIXITABINDUIPTCL YOUJIAOGAODEKANGZHONGLIUHUOXING,YICHENGWEINANZHIHUOFUFAHUANZHEKEXUANZEDEERXIANFANGAN。HANGUOYIXIANGYANJIUYINGYONGGDPFANGANZHILIAO25LIPTCLHUANZHE,QIZHONG14LIWEIPTCL-U,HUANZHE4 ZHOUQIGDP FANGANZHILIAOJIESHUHOUXINGASCT HUOJIXUWANCHENG6 ZHOUQIHUALIAO。CR LVWEI48%,PRLVWEI24%,ORR WEI72%,HUANZHEZHONGWEIPFSWEI9.3GEYUE。

JIEWAINK/TXIBAOLINBALIU(ENKTL)SHIZHONGGUOZUICHANGJIANDETXIBAOLINBALIU,XIFANGGUOJIADEFABINGLVDI,MUQIANSHANGWUBIAOZHUNHUALIAOFANGAN。JIWANGNCCNZHINANZHONGTUIJIANYIZUOXUANMENDONGXIANANMEIWEIJICHUDEFANGAN,LIRUSMILE FANGAN(DISAIMISONG+JIAANDIELING+YIHUANLINXIANAN+PEIMENDONGMEI+YITUOBOGAN)HEAspaMetDexFANGAN(PEIMENDONGMEI+JIAANDIELING+DISAIMISONG)ZAINK/TXIBAOLINBALIUZHILIAOZHONGBIAOXIANCHUJIAOHAODELINCHUANGLIAOXIAO,DANBULIANGFANYINGJIAOWEIMINGXIAN、ZHILIAOGUOCHENGBIJIAOFUZA,XUCHANGGUIMTXXUEYAONONGDUJIANCE,XUZHUYUANZHILIAO。

WEILEXUNZHAOGAOXIAODIDUDEZHILIAOFANGAN,WOZHONGXINZHENDUIENKTL KAIZHANLEDALIANGLINCHUANGYUJICHUYANJIU。BINGFABIAOLEDUOPIANZHONGYAODEWENZHANG。QIZHONGLINCHUANGSHANGBIJIAOTUCHUDESHI,ZHENGMINGLECHUANGXINXINGDEFANGANP-Gemox(PEIMENDONGMEILIANHEJIXITABINHEAOSHALIBO)DUINK/TLINBALIUGAOXIAO、DIDU、JIANBIANHEXINGJIABIGAO,TEBIESHIHEFAZHANZHONGGUOJIAHUANZHE。

龙岩炒股配资 BENRENCONG2013NIANKAISHI,DUOCIYINGYAOZAIDUOGE黄金配资 LINBALIUDAHUIFAYAN,BAOKUOMEIGUOXUEYENIANHUI(ASH)、MEIGUOT XIBAOLUNTANHEOUZHOUT XIBAOLUNTAN,TEBIEZAI2015NIAN6YUE,BENRENDAIBIAOTUANDUIZAI黄金配资 DINGJILINBALIUDAHUI—— RUISHILugano 黄金配资 LINBALIUDAHUISHANGJINXINGLEKOUTOUBAOGAOJIBIBAOJIAOLIU,FENBIEJIESHAOLEP-Gemox FANGANZHILIAOCHUZHIHEWANQIFUFAENKTLDEZHANGQISUIFANGJIEGUO。

P-Gemox DUOCHENGYOUDAOHUALIAOLIANHEKUODAQINFANYEFANGLIAOZHILIAO59 LIⅠ 、Ⅱ QIENKTL,4 NIANOS LVDA90.7±4.0%,4NIANPFSLVDA89.1±4.2%。P-GemoxFANGANYUSMILE FANGANLIAOXIAOXIANGSI,DANBULIANGFANYINGMINGXIANGENGDI,BULIANGFANYINGQING,TONGSHI,ZHILIAOCHENGBENYEMINGXIANJIAODI。2016 NIANZUIXINBANNCCNZHINANZHONG,ZAICITUIJIANWOMENTUANDUIDEP-Gemox FANGANZUOWEIZHILIAOENKTLDEHUALIAOFANGANZHIYI。

小结

龙岩炒股配资 ZONGSHANGSUOSHU,ZAILINBALIUJINGZHUNZHILIAOSHIDAI,DALIANGLINCHUANGYANJIUJIEGUOTISHIBAOHANJIXITABINDEHUALIAOFANGANKEXIANZHUTIGAONANZHIHUOFUFALINBALIUHUANZHEYUANQIOS,MUQIANZHUYAOYONGYUPTCLHEDLBCLDEERXIANHUALIAOFANGANJIENKTL,DANXIANGXINSUIZHEGENGDUOYANJIUDESHENRU,JIXITABINHUICHENGWEIKEFULINBALIUNAIYAOJIFUFADEZHONGYAOWUQI。


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